Tiny-TIM

SKU: NBSTK1000 | Manufacturer Part No: GA0120520

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The only device that can accurately mimic the dynamic conditions of the digestive system.

While conducting pharmaceutical and nutritional research, it’s important to know how drug dosages or food products behave in the gastrointestinal tract. Ideally, this research will be done in a timely, cost-effective manner before clinical studies are performed. To justify expensive, clinical studies, researchers can use tiny-TIM, an in vitro model, to mimic realistic gastrointestinal conditions.

The tiny-TIM system is a dynamic in vitro gastrointestinal model equipped with an advanced gastric compartment and a small intestinal compartment. The applications of tiny-TIM include:

Pharmaceutical Applications

  • Dosage form testing on the release, dissolution, and bioaccessibility of active pharmaceutical ingredients under fasted and fed-state conditions
  • Bio-equivalence studies
  • Drug-drug and drug-nutrient interactions
  • Proof-of-concept studies

Nutritional Applications

  • Digestibility of single ingredients or complex meals
    • Protein quality (DIAAS)
    • Carbohydrates (glycemic response)
    • Fats
  • Bioaccessibility of micronutrients or phytochemicals safety assessment studies

Benefits

  • Eliminates ethical constraints
  • Settings for adults, children & animals
  • Simple, user-friendly operation
  • Easy-to-use graphical touch screen
  • Bench-top system
  • Increased reproducibility versus in vivo studies
  • Fast and cost-efficient way to conduct research
  • System’s high predictive quality documented in more than 230 peer-reviewed publications

Tiny-TIM includes 3 modules

Gastrointestinal Module

  • Compartments simulate the shape and motility of the stomach and small intestine
  • Computerized peristaltic pump transports gastric content into small intestinal compartment

Dispensing Module

  • Pumps secretion fluids into GI compartments & fresh filtration/dialysis fluids through membrane units
  • Syringe pump dispenses fluids with high accuracy
  • 100mL graduated syringes allow for direct visual monitoring of dispensed volumes

Sampling Module

  • Sampling bottles collect filtrate or dialysis fluid from small intestinal compartment
  • Controlled, FMI pump fills bottle with pre-determined weight of sample
  • Different holders allow for various number of bottles and sampling sizes

General Features

  • Software controlled system operation
  • Pre-defined protocols
  • Low labor intensity
  • High accuracy and reproducibility
  • Standardized consumables available

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